Table 3 Subretinal fibrosis, sunset glow fundus, and nummular chorioretinal lesions within the first year and their associations with clinical and imaging parameters in 66 eyes of 33 patients with Vogt-Koyanagi-Harada disease followed for 12 months from acute onset

Parameters

Yes (n = 20)

No (n = 46)

Univariate analysis

P

Multivariate analysis

Odd ratio P CI 95%

Interval to start treatment, days, mean ± SD

34 ± 17.13

20.3 ± 13.73

0.025

1.17

0.004

1.05–1.3

median (interval)

32.5 (8–67)

17 (3–57)

FA total score at M0, mean ± SD

8.47 ± 2.01

5.83 ± 2.90

0.037

4.06

0.004

1.57–10.5

median (interval)

9 (5–13)

5.5 (0–9)

SRD at M3, eyes (%)

Yes

5 (83.3)

1 (16.7)

0.03

4.53

0.337

0.21–98.89

No

15 (25.0)

45 (75.0)

BALAD at M0, eyes (%)

Yes

14 (51.9)

13 (48.1)

< 0.001

12.04

0.011

1.75–82.6

No

4 (13.8)

25 (86.2)

Sunset glow fundus

Parameters

Yes (n = 38)

No (n = 28)

Univariate analysis

P

Multivariate analysis

Odd ratio P CI 95%

Interval to start treatment, days, mean ± SD

30.29 ± 16.95

16.54 ± 10.54

0.023

1.08

0.069

0.99–1.17

median (interval)

27 (8–67)

13 (3–44)

AU recurrence in the first year, eyes (%)

Yes

21 (80.8)

5 (19.2)

0.032

30.94

0.022

1.64–584

No

17 (42.5)

23 (57.5)

SRD area at M0, µm, mean ± SD

1,641,144 ± 1,564,898

517,212 ± 572,009

0.004

1

0.147

1

median (interval)

1,178,291

(10368-5999296)

299,206

(8713-2448347)

BALAD at M0, eyes (%)

Yes

22 (81.5)

5 (18.5)

0.008

14.78

0.002

2.74–79.6

No

12 (41.4)

17 (58.6)

Nummular chorioretinal lesions

Parameters

Yes (n = 26)

No (n = 40)

Univariate analysis

P

Multivariate analysis

Odd ratio P CI 95%

Interval to start treatment, days, mean ± SD

33.19 ± 17.15

18.78 ± 12.45

0.018

median (interval)

29.5 (8–67)

16 (3–51)

FA total score at M0, mean ± SD

8.26 ± 2.03

5.68 ± 2.95

0.042

median (interval)

9 (5–13)

5.5 (0–9)