Fig. 2

Multimodal imaging of a 26-year-old male patient diagnosed with Vogt-Koyanagi-Harada disease 32 days after disease onset. Initial visual acuity was counting fingers in both eyes. Treatment consisted of 3-day methylprednisolone pulse therapy followed by 50 mg of oral prednisone (1 mg/kg/day). At M1, best-corrected visual acuity (BCVA) was 0.3 logMAR in the right eye and 0.2 logMAR in the left eye. At M12, BCVA was 0 logMAR at both eyes and was taking 2.5 mg of prednisone and 150 mg of azathioprine. Initial retinal imaging revealed bilateral, extensive serous detachment and optic disc hyperemia and edema in both eyes (A and B). Enhanced Depth Imaging Optical Coherence Tomography (EDI-OCT), horizontal single scan through the fovea at initial presentation, there was an increased choroidal thickness and serous retinal detachment (SRD) with bacillary layer detachment (BALAD) (C, right eye; D, left eye). Retinal imaging at 12 months of follow-up demonstrated fundus depigmentation (sunset glow fundus), areas of atrophy, subretinal fibrosis and pigment disruption in both eyes (E and F). Enhanced depth imaging optical coherence tomography, horizontal single scan over the fovea, showed thickened choroid and subretinal fibrosis in the right eye (G) and in the left eye (H)