Fig. 3

The positioning of the Inner and outer blood-retina barriers. The I nner blood-retina barrier (iBRB) Is created by the endothelial cells that line the blood vessels in the inner part of the retina. These blood vessels supply the retina up to the outer plexiform layer (OPL), and the layer of photoreceptor cells remains without blood vessels. The outer blood-retina barrier (oBRB) is formed by the retinal pigment epithelial cells (RPE) and controls the movement of substances between the retina and the choroid. In this context, we also have the Inner limiting membrane (ILM), ganglion cell layer (GCL), inner nuclear layer (INL), outer nuclear layer (ONL), and outer segments (OS)