Fig. 1

The retinal pigment epithelium (RPE) and the Bruch membrane have a significant relationship. (A, C) The Bruch membrane is a barrier separating the RPE from the choriocapillaris. It is important to observe the intricate interdigitation of the apical processes of the RPE with the photoreceptor outer segments, as well as the infoldings of the basal surface. (B) The diagram illustrates the thickness of the various layers of the Bruch membrane, starting from the top: the basement membrane of the RPE, the inner collagenous layer, an elastic layer, an outer collagenous layer, and the basement membrane of the choriocapillaris. The apical processes of the RPE are identified as APRPE