Fig. 1

Pegcetacoplan treatment effect model. (A) The progression prediction algorithm provides a three-line illustration in en-face maps: retinal pigment epithelial and outer retinal atrophy (RORA) area at baseline (dark blue), 80% lesion growth at 2 years (light blue), and 100% growth (natural course) at 2 years (pink). The pink area corresponds to the calculated treatment effect (20% growth reduction). (B) En-face projection of segmented RORA area shown with the localizer (in yellow). The foveal location is indicated by the position of the localizer. (C) Corresponding B-scan