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Table 1 The association between baseline optical coherence tomography markers of patients and the change in BCVA from baseline to months 3 and 12

From: Predictive value of different baseline optical coherence tomography biomarkers for visual acuity changes in neovascular age-related macular degeneration

Variable

Number (%)

BCVA change in month 3 value

BCVA change in month 12 value

Multivariable‡

Mean ± SD

Median

P†

Mean ± SD

Median

P†

SIPED

        

 No

33 (37.1%)

9.4 ± 13.5

8

0.051

8.5 ± 17.8

12

0.189

0.025

 Yes

56 (62.9%)

4 ± 10.6

5.5

 

3.7 ± 14.6

5.5

  

SHRM

        

 No

14 (15.7%)

1.8 ± 9.8

1.5

0.1

5.3 ± 11

7.5

0.92

–

 Yes

75 (84.3%)

6.8 ± 12.2

7

 

5.6 ± 16.8

7.5

  

SRF

        

 No

15 (16.9%)

0.7 ± 11.9

−1

0.065

−0.3 ± 19.8

5

0.211

0.856

 Yes

74 (83.1%)

7.1 ± 11.8

7

 

6.7 ± 15.1

8

  

IRF

        

 No

36 (40.4%)

8.3 ± 9

7

0.124

11.1 ± 10

10.5

0.002

0.021

 Yes

53 (59.6%)

4.5 ± 13.6

5.5

 

1.6 ± 18.2

3.5

  

HRF (subretinal)

        

 No

20 (22.5%)

2.7 ± 12.1

2

0.125

1.7 ± 19.5

7

0.309

–

 Yes

69 (77.5%)

7 ± 11.9

7

 

6.6 ± 14.9

7.5

  

HRF (intraretinal)

        

 No

22 (24.7%)

6.8 ± 8

7.5

0.688

8.2 ± 9.2

6.5

0.252

–

 Yes

67 (75.3%)

5.8 ± 13.1

5.5

 

4.7 ± 17.6

8

  

SDD

        

 No

73 (82.0%)

6.9 ± 11.3

7

0.234

6.7 ± 16.1

9

0.172

–

 Yes

16 (18.0%)

2.5 ± 14.3

5.5

 

1 ± 15.1

3

  

Pre-choroidal cleft

        

 No

84 (94.4%)

5.6 ± 11.9

6

0.027

5.2 ± 16.1

7

0.184

0.01

 Yes

5 (5.6%)

18 ± 11.5

19

 

14.3 ± 14

13

  
  1. †Based on GEE analysis
  2. ‡Based on interaction of Time and variable in a multivariable GEE analysis. All variables which have a P-value < 0.100 in simple GEE analysis at any time (3 or 12 months) entered into this analysis. Bold values indicate statistically significant differences
  3. BCVA best-corrected visual acuity, SIPED shallow irregular pigment epithelial detachment, SHRM subretinal hyperreflective material, SRF subretinal fluid, IRF intraretinal fluid, HRF hyperreflective foci, SDD subretinal drusenoid deposit