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Table 3 Manual and AI-assisted quantification of metric OCT biomarkers and volumetric analysis according to Naïve and switch status

From: Faricimab efficacy in type 1 macular neovascularization: AI-assisted quantification of pigment epithelium detachment (PED) volume reduction over 12 months in Naïve and switch eyes

Biomarker

Follow-up

Type 1 MNV

P-value

Switch

Naïve

(N = 52)

(N = 13)

Mean (SD)

CRT (µm)

Baseline

379 (187)

463 (207)

0.118

3-month

326 (165)

293 (123)

0.920

6-month

326 (181)

276 (96)

0.755

12-month

324 (171)

263 (113)

0.234

PED Height (µm)

Baseline

246 (177)

254 (99.3)

0.327

3-month

210 (155)

130 (100)

0.022*

6-month

201 (156)

124(74)

0.101

12-month

195 (152)

121 (80)

0.699

PED Volume (nL)

Baseline

844 (995)

676 (680)

0.727

3-month

706 (860)

278 (309)

0.049*

6-month

707 (905)

379 (425)

0.296

12-month

689 (841)

265 (259)

0.043*

  1. Legenda – OCT: optical coherence tomography; SD: standard deviation; N: absolute frequency; CRT: central retinal thickness; PED: pigment epithelium detachment (Height and Volume); p-value: probability level derived by the Mann-Whitney U test