Fig. 3

Representation of the longitudinal changes in pigment epithelium detachment (PED) volume in a treatment-naïve patient. Images obtained from the Discovery^® platform (Discovery OCT Fluid and Biomarker Detector, RetinAI AG, Switzerland). (Top row) Baseline multimodal imaging of exudative Type 1 macular neovascularization (T1 MNV). (A) Multicolor imaging shows the presence of a subfoveal PED associated with subretinal fluid (SRF); (B) fluorescein angiography (FA) and (C) and indocyanine green angiography (ICGA) confirm the presence of neovessels in the sub-RPE space; (Middle row) (D) baseline horizontal optical coherence tomography (OCT) scan shows the presence of subretinal hyperreflective material (SHRM) overlying a fibrovascular PED (insert: segmentation in blue indicates PED volume); (E) 6-month follow-up examination displays a decreasing trend of PED volume, with residual subretinal exudation; (F) a stabilization of the T1 MNV complex is observed at final follow-up; (Lower row) (G-H-I) en-face SLO infrared (IR) images with superimposed colorimetric scale of PED Volume display the longitudinal changes after IVT Faricimab treatment (total 8 injections, q8w after loading phase)