Fig. 1

Representation of the optical coherence tomography (OCT) biomarkers assessed in the study. (A) Type 1 Macular Neovascularization (T1 MNV) is characterized by an ingrowth of neovessels in the sub-RPE space leading to varying types of pigment epithelium detachments (PEDs): dashed line delineates a fibrovascular PED associated with outward exudation (arrowhead) and typical subretinal fluid (SRF; arrow) at the edge of the neovascular complex (dashed lines); (B) accumulation of fluid may also occur in the intraretinal space (inward exudation) with the creation of intraretinal fluid (IRF) and cystoid spaces (circle), subretinal fluid (SRF) is indicated with arrows; (C) T1 MNV may also present with a predominantly outward exudation, even in absence of a posterior bowing at theBruch’s Membrane (arrowhead). In particular, PED volume (dashed lines) was considered as an indicator of the fluid accumulation arising from active MNV components i.e., intralesional + outward fluid component