Fig. 1

Workflow for longitudinal tracking of microperimetry (MP) sensitivities within the GA junctional zone. Baseline (visit 1) MP scanning laser ophthalmoscopy (SLO) images (panel A) are registered with baseline fundus autofluorescence (FAF) images (panel B), allowing the MP stimulus points to be overlaid on the FAF image (panels C, D). Each MP stimulus point is associated with a signed distance from the lesion margin, as defined by FAF lesion tracing; distances, in micrometers, are shown next to each MP stimulus point. Positive and negative distances correspond to points outside and inside regions of atrophy, respectively. The junctional zone comprising all points within 250 μm of the lesion boundary is shaded red; those MP stimulus positions within the junctional zone have filled markers, and those outside the junctional zone have unfilled markers