Table 2 Whole disc vascular density, inside disc vascular density, Peripapillary vascular density, and retinal nerve fiber layer (RNFL) thickness 1 month, and 3 months after pan-retinal photocoagulation (PRP) or intravitreal bevacizumab (IVB) injection. Diff: difference; CI: confidence interval
Variable | Time |  | Treatment | Diff | 95% CI | P†| ||
|---|---|---|---|---|---|---|---|---|
PRP (Mean ± SD) | IVB (Mean ± SD) | Lower | Upper | |||||
Whole disc | Â | Â | Â | Â | Â | Â | Â | Â |
|  | Baseline |  | 45.5 ± 3.2 | 46.4 ± 3.4 | -0.88 | -2.75 | 0.99 | 0.357 |
|  | Month 1 |  | 44 ± 3.3 | 47.4 ± 2.8 | -3.33 | -5.09 | -1.57 | 0.002 |
|  | Change 0–1 |  | -1.54 ± 3.25 | + 0.99 ± 3.08 | -2.45 | -4.29 | -0.61 | 0.009 |
|  | P-within‡ |  | 0.032 | 0.327 |  |  |  |  |
|  | Month 3 |  | 44.2 ± 3.2 | 47.5 ± 3.3 | -3.22 | -1.27 | -5.16 | 0.001 |
|  | Change 0–3 |  | -1.32 ± 2.33 | + 1.15 ± 3.69 | -2.63 | -0.98 | -4.28 | 0.002 |
|  | P-within‡ |  | 0.004 | 0.352 |  |  |  |  |
|  | Change 1–3 |  | -0.19 ± 2.41 | + 0.16 ± 2.89 | -0.48 | -1.85 | 0.9 | 0.497 |
|  | P-within‡ |  | 0.999 | 0.99 |  |  |  |  |
Inside disc | Â | Â | Â | Â | Â | Â | Â | Â |
|  | Baseline |  | 47.7 ± 6.1 | 43.1 ± 6.3 | 4.44 | 0.81 | 8.08 | 0.017 |
|  | Month 1 |  | 44.7 ± 5.6 | 45 ± 5.7 | -0.5 | -3.26 | 4.23 | 0.795 |
|  | Change 0–1 |  | -2.99 ± 6.33 | + 1.85 ± 6.89 | -4.58 | -8.41 | -0.75 | 0.019 |
|  | P-within‡ |  | 0.032 | 0.485 |  |  |  |  |
|  | Month 3 |  | 44.7 ± 5.2 | 44 ± 7.7 | 1.02 | -3.2 | 5.23 | 0.636 |
|  | Change 0–3 |  | -3.68 ± 5.47 | + 0.89 ± 8.11 | -4.68 | -8.46 | -0.91 | 0.015 |
|  | P-within‡ |  | 0.001 | 0.935 |  |  |  |  |
|  | Change 1–3 |  | -1.17 ± 4.59 | -0.95 ± 6.68 | -1.24 | -3.21 | 0.72 | 0.215 |
|  | P-within‡ |  | 0.871 | 0.865 |  |  |  |  |
Peripapillary vascular density | Â | Â | Â | Â | Â | Â | Â | Â |
|  | Baseline |  | 47.7 ± 3.6 | 49.3 ± 4.4 | -1.67 | -0.06 | 3.95 | 0.153 |
|  | Month 1 |  | 45.8 ± 3.9 | 50.3 ± 3.1 | -4.33 | -6.38 | -2.29 | 0.001 |
|  | Change 0–1 |  | -1.85 ± 3.56 | + 0.95 ± 3.86 | -2.95 | -4.87 | -1.06 | 0.002 |
|  | P-within‡ |  | 0.016 | 0.552 |  |  |  |  |
|  | Month 3 |  | 45.7 ± 3.8 | 50.2 ± 3.9 | -4.26 | -6.63 | -1.88 | 0.001 |
|  | Change 0–3 |  | -1.83 ± 3.55 | + 0.9 ± 3.74 | -2.74 | -4.78 | -0.69 | 0.009 |
|  | P-within‡ |  | 0.011 | 0.58 |  |  |  |  |
|  | Change 1–3 |  | -0.39 ± 2.93 | + 0.06 ± 3.05 | -0.42 | -1.97 | 1.14 | 0.599 |
|  | P-within‡ |  | 0.99 | 0.99 |  |  |  |  |
RNFL thickness | Â | Â | Â | Â | Â | Â | Â | Â |
|  | Baseline |  | 104.6 ± 17.5 | 112 ± 19.8 | -5.15 | -18.07 | 7.77 | 0.434 |
|  | Month 1 |  | 114.2 ± 15.6 | 109.3 ± 19.7 | 5.84 | -6.39 | 18.06 | 0.349 |
|  | Change 0–1 |  | + 9.52 ± 7.32 | -2.71 ± 5.46 | -11.65 | -7.5 | -15.79 | 0.001 |
|  | P-within‡ |  | 0.002 | 0.58 |  |  |  |  |
|  | Month 3 |  | 110.7 ± 16.3 | 107.4 ± 18 | 5.66 | -6.15 | 17.47 | 0.348 |
|  | Change 0–3 |  | + 5.05 ± 7.07 | -4.62 ± 5.55 | + 9.22 | -4.93 | -13.51 | 0.001 |
|  | P-within‡ |  | 0.001 | 0.001 |  |  |  |  |
|  | Change 1–3 |  | -4.63 ± 7.37 | -1.9 ± 5.16 | -2.81 | -6.48 | 0.86 | 0.134 |
|  | P-within‡ |  | 0.009 | 0.001 |  |  |  |  |